Ye Shen

Epidemiology & Biostatistics, Institute of Gerontology,
Associate Professor

Epidemiology & Biostatistics, Institute of Gerontology,

  • PhD, Biostatistics, Yale University, 2011
  • BS, Statistics, Fudan University, 2003
Areas of Expertise
  • longitudinal data analysis
  • spatial statistics
  • recurrent event modeling
  • study design
  • causal inference (matching/propensity score/SEM)
  • epidemiology
  • ASA
  • IMS
Course Instruction
  • Introductory Biostatistics
  • Categorical Data Analysis
  • Data Management and Computing
  • Advanced Biostatistics
Research Interests
  • joint modeling
  • longitudinal data analysis
  • spatial statistics
  • recurrent event modeling
  • survival analysis
  • semi-parametric regression methods
  • missing data problems in clinical trials
Selected Publications

Sung M, Shen Y*, Handel A, Bahl J, Ross TM. Longitudinal Assessment of Immune Responses to Repeated Annual Influenza Vaccination in a Human Cohort of Adults and Teenagers. Frontiers in Immunology. 2021; 12: 472.

Cheng Y, Li Y, Smith M, Li C, and Shen Y. Analyzing Evidence-Based Falls Prevention Data with Significant Missing Information Using Variable Selection after Multiple Imputation. Journal of Applied Statistics. 2021; In Press.

Ge Y, Chen Z, Handel A, Martinez L, Xiao Q, …, and Shen Y. The impact of social distancing, contact tracing, and case isolation interventions to suppress the COVID-19 epidemic: A modeling study. Epidemics. 2021; 36: 100483.

Shen Y, Li C, Dong H, Wang Z, Martinez L, …, and Xu G. Community outbreak investigation of SARS-CoV-2 transmission among bus riders in eastern China. JAMA Internal Medicine. 2020; 180(12): 1665-1671.

Shen Y, Xu W, Li C, Handel A, Martinez L, Ling F, … and Chen E. A cluster of novel coronavirus disease 2019 infections indicating person-to-person transmission among casual contacts from social Gatherings: an outbreak Case-Contact investigation. Open Forum Infectious Diseases. 2020; 7(6): ofaa231.

Shen Y, Sung M, King C, Binder S, Kittur N, Whalen C, Colley D. Modeling approaches to predicting persistent hotspots in SCORE studies for gaining control of schistosomiasis mansoni in Kenya and Tanzania. Journal of Infectious Diseases. 2020; 221(5): 796-803.

Martinez L, Cheng W, Wang X, Ling F, Mu L, Li C, Huo X, Ebell M, Huang H, Zhu L, Li C, Handel A, Chen E, Shen Y. Derivation and validation of a risk classification model to predict mortality among laboratory-confirmed avian influenza A H7N9 patients: a population-based observational cohort study. Journal of Infectious Diseases. 2019; 220(11): 1780-1789.

Shen Y, Wiegand RE, Olsen A, King CH, Kittur N, Binder S, Zhang F, Whalen CC, Secor WE, Montgomery SP, Mwinzi PNM, Magnussen P, Kinung’hi S, Campbell CH, Colley DG. Five-Year Impact of Different Multi-Year Mass Drug Administration Strategies on Childhood Schistosoma mansoni-Associated Morbidity: A Combined Analysis from the Schistosomiasis Consortium for Operational Research and Evaluation Cohort Studies in the Lake Victoria Regions of Kenya and Tanzania. Am J Trop Med Hyg. 2019; 101(6):1336-1344.

Shen L, Li C, Wang Z, Zhang R, Shen Y, Miles T, Wei J, Zou Z. Early-life exposure to severe famine is associated with higher methylation level in the IGF2 gene and higher total cholesterol in late adulthood: the Genomic Research of the Chinese Famine (GRECF) study. Clin Epigenetics. 2019;11(1):88.

Martinez L, Shen Y, Handel A, Chakraburty S, Stein C, Malone L, Boom HW, Quinn FD, Joloba ML, Whalen CC, Zalwango S. Effectiveness of WHO’s Screening Algorithm for Child Contacts of Tuberculosis Cases in Resource-constrained Areas: A Prospective Cohort Study in Uganda. Lancet Respiratory Medicine. 2018;6:276–286.

Heckman TG, Markowitz JC, Heckman BD, Woldu H, Anderson T, Lovejoy TI, Shen Y, Sutton M, Yarber W. A randomized clinical trial showing persisting reductions in depressive symptoms in HIV-infected rural adults following brief telephone-administered Interpersonal Psychotherapy. Annals of Behavioral Medicine. 2018;52(4):299-308.

Martinez L, Handel A, Shen Y, Chakraburty S, Quinn FD, Stein CM, Malone LL, Zalwango S, Whalen CC. A Prospective Validation of a Clinical Algorithm to Detect Tuberculosis in Child Contacts. American Journal of Respiratory and Critical Care Medicine. 2018;197(9):1214-1216.

Li C, Miles T, Shen L, Shen Y, Liu T, Zhang M, Li S, Huang C. Early-life exposure to severe famine and subsequent risk of depressive symptoms in late adulthood: the China Health and Retirement Longitudinal Study. The British Journal of Psychiatry. 2018;213(4):579-86.

Shen Y, King CH, Binder S, Zhang F, Whalen CC, Secor WE, Montgomery SP, Mwinzi PN, Olsen A, Magnussen P, Kinung’hi S. Protocol and baseline data for a multi-year cohort study of the effects of different mass drug treatment approaches on functional morbidities from schistosomiasis in four African countries. BMC infectious diseases. 2017;17(1):652.

Martinez L, Shen Y, Mupere E, Kizza A, Hill PC, Whalen CC. Transmission of Mycobacterium Tuberculosis in Households and the Community: A Systematic Review and Meta-Analysis. American Journal of Epidemiology. 2017;185(12):1327-39.

Shen Y, Huang H, Guan Y. A conditional estimating equation approach for recurrent event data with additional longitudinal information. Statistics in Medicine. 2016;35(24):4306-19.

Chu Y, Dai L, Qi S, Smith ML, Huang H, Li Y, Shen Y. Challenges from variation across regions in cost effectiveness analysis in multi-regional clinical trials. Frontiers in Pharmacology. 2016;7.

Zhao L, Zhang X, Shen Y, Fang X, Wang Y, Wang F. Obesity and iron deficiency: a quantitative meta‐analysis. Obesity Reviews. 2015;16(12):1081-93.

Zhang X, Davidson EA, Mauzerall DL, Searchinger TD, Dumas P, Shen Y. Managing nitrogen for sustainable development. Nature. 2015;528(7580):51.

Shen Y, Miao J, Li C, Fang L, Cao S, Zhang M, et al. A meta-analysis of the fusion rate from surgical treatment for odontoid factures: anterior odontoid screw versus posterior C1–C2 arthrodesis. European Spine Journal. 2015;24(8):1649-57.

Shen Y, Anderson A, Sinha R, Li Y. Joint modeling tumor burden and time to event data in oncology trials. Pharmaceutical Statistics. 2014;13(5):286-93.

Ebell MH, Jang W, Shen Y, Geocadin RG. Development and validation of the Good Outcome Following Attempted Resuscitation (GO-FAR) score to predict neurologically intact survival after in-hospital cardiopulmonary resuscitation. JAMA Internal Medicine. 2013;173(20):1872-8.

Guan Y, Shen Y. A weighted estimating equation approach for inhomogeneous spatial point processes. Biometrika. 2010;97(4):867-80.

Janket S-J, Shen Y, Baird AE. Why must new cardiovascular risk factors be carefully re-assessed prior to clinical application? European Heart Journal. 2008;29(10):1336-7.

Janket S-J, Shen Y, Meurman JH. Letter by Janket et al regarding article, “Use and misuse of the receiver operating characteristic curve in risk prediction”. Circulation. 2007;116(6):e132.