Ye Shen

Epidemiology & Biostatistics, Institute of Gerontology,
Associate Department Head & Associate Professor

Epidemiology & Biostatistics, Institute of Gerontology,

  • PhD, Biostatistics, Yale University, 2011
  • BS, Statistics, Fudan University, 2003
Areas of Expertise
  • longitudinal data analysis
  • spatial statistics
  • recurrent event modeling
  • study design
  • causal inference (matching/propensity score/SEM)
  • epidemiology
  • ASA
  • IMS
Course Instruction
  • Introductory Biostatistics
  • Categorical Data Analysis
  • Data Management and Computing
  • Advanced Biostatistics
Research Interests
  • joint modeling
  • longitudinal data analysis
  • spatial statistics
  • recurrent event modeling
  • survival analysis
  • semi-parametric regression methods
  • missing data problems in clinical trials
Selected Publications

Wang, F., Xu, S., Qin, Y., Shen Y., and Li Y. Sparse clustering for customer segmentation with high-dimensional mixed-type data. The Annals of Applied Statistics. 2024; In press.

Sung, M. H., Billings, W. Z., Carlock, M. A., Hanley, H. B., Bahl, J., Handel, A., Ross, T.M., and Shen, Y*. Assessment of Humoral Immune Responses to Repeated Influenza Vaccination in a Multiyear Cohort: A 5-Year Follow-up. The Journal of Infectious Diseases. 2024; 229(2), 322-326.

Zhang, Y., Sun, Y., Yu, Q., Song, S., Brenna, J. T., Shen, Y.*, and Ye, K*. Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: a population-based cohort study in UK Biobank. eLife. 2024; In press.

Li Yang, Yang Haoyu, Yu Haochen, Huang Hanwen, and Shen Ye*. Penalized weighted least-squares estimate for variable selection on correlated multiply imputed data. Journal of the Royal Statistical Society Series C: Applied Statistics. 2023; 72(3), 703-717.

Cheng Y, Li Y, Smith M, Li C, and Shen Y*. Analyzing evidence-based falls prevention data with significant missing information using variable selection after multiple imputation. Journal of Applied Statistics. 2023; 50(3), 724-743.

Tan Jianbin, Shen Ye, Ge Yang, Martinez Leonardo, and Huang Hui. Age-related model for estimating the symptomatic and asymptomatic transmissibility of covid-19 patients. Biometrics. 2023; 79(3), 2525-2536.

Li Yang, Yang Haoyu, Yu Haochen, Huang Hanwen, and Shen Ye*. Penalized estimating equations for generalized linear models with multiple imputation. The Annals of Applied Statistics. 2023; 17(3), 2345-2363.

Liu, Q., You, N., Wen, J., Wang, J., Ge, Y., Shen, Y., …, and Martinez, L. Yield and efficiency of a population-based mass tuberculosis screening intervention among persons with diabetes in Jiangsu Province, China. Clinical Infectious Diseases. 2023; 77(1): 103–111.

Li C, Shen Y*, Xiao Q, Rathbun SL, Huang H, and Guan Y. Mean corrected generalized estimating equations for longitudinal binary outcomes with report bias. Statistical Methods in Medical Research. 2022; 31 (2): 315-333.

Li Y, Wang F, Shen Y, Qin Y, and Si J.  Selection of mixed copula for association modeling with tied observations. Statistical Methods and Applications. 2022; 31(5), 1127-1180.

Ge Y, Martinez L, Sun S, Chen Z, Zhang F, …, and Shen Y*. COVID-19 transmission dynamics among close contacts of index patients with COVID-19. JAMA Internal Medicine. 2021; 181(10): 1343-50.

Sung M, Shen Y*, Handel A, Bahl J, and Ross TM. Longitudinal assessment of immune responses to repeated annual influenza vaccination in a human cohort of adults and teenagers. Frontiers in Immunology. 2021; 12: 472.

Liu, Q., You, N., Pan, H., Shen, Y., Lu, P., Wang, J., … , and Martinez, L. Glycemic trajectories and treatment outcomes of patients with newly diagnosed tuberculosis: a prospective study in Eastern China. American Journal of Respiratory and Critical Care Medicine. 2021; 204(3), 347-356.

Ge Y, Chen Z, Handel A, Martinez L, Xiao Q, …, and Shen Y*. The impact of social distancing, contact tracing, and case isolation interventions to suppress the COVID-19 epidemic: A modeling study. Epidemics. 2021; 36: 100483.

Shen Y, Li C, Dong H, Wang Z, Martinez L, …, and Xu G. Community outbreak investigation of SARS-CoV-2 transmission among bus riders in eastern China. JAMA Internal Medicine. 2020; 180(12): 1665-1671.

Shen Y, Sung M, King C, Binder S, Kittur N, Whalen C, and Colley D. Modeling approaches to predicting persistent hotspots in SCORE studies for gaining control of schistosomiasis mansoni in Kenya and Tanzania. Journal of Infectious Diseases. 2020; 221(5): 796-803.

Martinez L, Cheng W, Wang X, Ling F, Mu L, Li C, Huo X, Ebell M, Huang H, Zhu L, Li C, Handel A, Chen E, and Shen Y*. Derivation and validation of a risk classification model to predict mortality among laboratory-confirmed avian influenza A H7N9 patients: a population-based observational cohort study. Journal of Infectious Diseases. 2019; 220(11): 1780-1789.

Woldu H, Heckman TG, Handel A, and Shen Y*. Applying functional data analysis to assess tele-interpersonal psychotherapy’s efficacy to reduce depression. Journal of Applied Statistics. 2019; 46(2): 203-16.

Martinez L, Shen Y, Handel A, Chakraburty S, Stein C, Malone L, Boom HW, Quinn FD, Joloba ML, Whalen CC, and Zalwango S. Effectiveness of WHO’s Screening Algorithm for Child Contacts of Tuberculosis Cases in Resource-constrained Areas: A Prospective Cohort Study in Uganda. Lancet Respiratory Medicine. 2018; 6: 276–286.

Martinez L, Shen Y, Mupere E, Kizza A, Hill PC, and Whalen CC. Transmission of Mycobacterium Tuberculosis in Households and the Community: A Systematic Review and Meta-Analysis. American Journal of Epidemiology. 2017; 185(12): 1327-39.

Shen Y, Huang H, and Guan Y. A conditional estimating equation approach for recurrent event data with additional longitudinal information. Statistics in Medicine. 2016; 35(24): 4306-19.

Zhang X, Davidson EA, Mauzerall DL, Searchinger TD, Dumas P, and Shen Y. Managing nitrogen for sustainable development. Nature. 2015; 528(7580): 51-59.

Shen Y, Anderson A, Sinha R, and Li Y. Joint modeling tumor burden and time to event data in oncology trials. Pharmaceutical Statistics. 2014; 13(5): 286-93.

Ebell MH, Jang W, Shen Y, and Geocadin RG. Development and validation of the Good Outcome Following Attempted Resuscitation (GO-FAR) score to predict neurologically intact survival after in-hospital cardiopulmonary resuscitation. JAMA Internal Medicine. 2013; 173(20): 1872-8.

Guan Y, Shen Y. A weighted estimating equation approach for inhomogeneous spatial point processes. Biometrika. 2010; 97(4): 867-80.